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Exploring the metabolic mysteries: Mechanistic insights into lactylation-mediated regulation of autoimmune diseases

Autoimmunity Reviews 2026

Nan Kang, Wei Chen, Jian Li, Xiao Wang, Yang Liu, Hao Zhang, Fang Yuan, Ke Hu, Ming Xu, Ling Sun

乳酰化 自身免疫性疾病 代谢重编程 Warburg效应

揭示乳酰化修饰在自身免疫性疾病中的代谢调控机制和潜在治疗策略

Histone modification clocks for robust cross-species biological age prediction and elucidating senescence regulation

Proceedings of the National Academy of Sciences 2026

Zhixin Niu, Jie Liu, Wei Zhang, Yang Chen, Min Li, Xin Zhou, Qiang Wang, Fang Liu, Jing Yang, Hao Wu

表观遗传 组蛋白修饰 生物年龄 衰老

开发组蛋白修饰表观遗传时钟，实现跨物种生物年龄预测，揭示衰老调控机制

Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

eLife 2026

Yatendra Kumar, Debayan Sengupta, Elisa Frances, Ramona Iordache, Michele Singh, Zheng Fu, Hao Wang, Kevin Harris, Michael Garcia, Wolfgang Berg

H3K115ac 组蛋白乙酰化 脆弱核小体 CpG岛

揭示H3K115乙酰化与CpG岛启动子脆弱核小体的关联及其在活性调控元件中的功能

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